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About This Game
Dive into the microscopic world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive a variety of microbes across 6 game modes, each with multiple "depths".
Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
Bomb + Bomb doubles down on explosive power to make Bazooka!
Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!

49 Turrets with unique strengths and functions
96 Perks to mix and match that drastically change how you play
75 Weapon & Turret Mods that can turn shots into sticky laser mines or bouncing fireballs
64 Mutations alter the challenges you face each run

20-minute Runs that can be continued in Endless Mode
75 Bassy Electronic Tunes that adapt to the current mood & intensity
Cosmetics like spider legs and tank tread
Accessibility Settings for colourblindness, motion sickness, and even arachnophobia!
100 Steam Achievements
Steam Trading Cards
Cloud Save
Plays great on Steam Deck!!!

Screenshots
User Reviews
Seems simple at first, but with so many different enemies, turrets, perks, and weapons, there's a ton of stuff to do. Experimenting with weapons usually results in finding some combinations that can either look cool, or obliterate enemies with ease. The only negative is that some of the Turret Trials are a little too heavy on luck, but other than that, amazing game. Even after getting true 100%, it's still fun
game needs a good tutorial UI is barely usable with controller
Pretty good, funky music, feels cool to work out the good combos, and you can make some pretty patterns.
It's got some interesting concepts, and the gameplay is mostly fun. Doing runs with different builds is initially interesting, but some of the variants are just not worth it. Overall, it's a good $4-$7 USD game. I don't think it is worth $12 USD. Wait for a sale. Even if you're not going to buy it, give the demo a try. I still liked it, though.
Fun
Handholdy, Buggy, and just overall a really straightforward experience of a game. The depth is there, I will admit...but getting to that point is a fairly straightforward grind. Start a run, sleep through the first handful of waves, hope you find one good perk, die because the game outscales you to the point where you physically can't win as your stats are just too low, go back to menu, start again, get yelled at to look at stuff you don't have or care about, get prevented from playing until you open and close the perk screen like ten times, start a new run, get told "no" when you try to buy something because the developer thinks you're incapable of rational thought, and then grind again until your stats go up again, and die and grind until you have enough stats. After that, winning is a matter of course, not challenge. It's just too basic, too handholdy, too buggy (I've had the shop straight up softlock me multiple times, preventing doing anything but alt+F4-ing out of the game and ...
If you're a power simulator autist, this is for you.
Unfortunately can't really recommend this one. I tried to play it but it felt dull, weapons felt boring and enemies just become bullet sponges with no real thought behind them. I had to lose on purpose just to see what else the game had to offer. There is nothing inherently bad, just nothing to make you stick around
It could be fun or it could be this.
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System Requirements
Minimum
- OS: Windows 10
- Storage: 800 MB available space
- Additional Notes: Change Quality / Render Scale in SETTINGS if low FPS
Recommended
- OS: Windows 10
- Storage: 800 MB available space
- Additional Notes: Change Quality / Render Scale in SETTINGS if low FPS
FAQ
How much does Genome Guardian cost?
Genome Guardian costs $11.99.
What are the system requirements for Genome Guardian?
Minimum: Minimum: OS: Windows 10 Storage: 800 MB available space Additional Notes: Change Quality / Render Scale in SETTINGS if low FPS Recommended: Recommended: OS: Windows 10 Storage: 800 MB available space Additional Notes: Change Quality / Render Scale in SETTINGS if low FPS
What platforms is Genome Guardian available on?
Genome Guardian is available on Windows PC.
Is Genome Guardian worth buying?
Genome Guardian has 81% positive reviews from 21 players.
When was Genome Guardian released?
Genome Guardian was released on May 7, 2024.
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